Differential incorporation of 1-β-D-arabinofuranosylcytosine and 9-β-D-arabinofuranosylguanine into nuclear and mitochondrial DNA
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چکیده
منابع مشابه
Incorporation of 1-/3-D-Arabinofuranosylcytosine into DMA from Herpes Simplex Virus Resistant to 9-0-D-Arabinofuranosyladenine1
We have demonstrated previously that 1-0-D-arabinofuranosylcytosine (ara-C) incorporates specifically in cellular DMA and that the formation of (ara-C)DNA correlates significantly with inhibition of DMA synthesis and loss of clonogenic survival. Similar results have been obtained with 9-0-D-arabinofuranosyladenine (ara-A). These findings have been extended by studying the incorporation of ara-C...
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متن کاملEnhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
We evaluated the interaction of a biochemically active concentration of cyclopentenyl cytosine (CPE-C), an investigational antimetabolite which inhibits CTP synthetase, on the cytotoxicity of arabinosyl-5-azacytosine (Ara-AC) and 1-beta-D-arabinofuranosylcytosine (Ara-C) in HCT 116 colon carcinoma cells. A 3-h exposure to 0.5 microM CPE-C depleted CTP pools by over 90% and decreased dCTP pools ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2000
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(00)01569-6