Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

Differential effects of cytolytic T cell subsets on intracellular infection.

In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4(-)CD8(-) (double-negative) T cells and CD8(+) T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4(-)CD8(-) T cells was mediated by Fas-FasL interaction and had no effect on the ...

The Effect of Mafosfamide on Differential Activation of T-helper Subsets

Cd4+ T Cell Subsets during Virus Infection

To analyze the antiviral protective capacities of CD4(+) T helper (Th) cell subsets, we used transgenic T cells expressing an I-A(b)-restricted T cell receptor specific for an epitope of vesicular stomatitis virus glycoprotein (VSV-G). After polarization into Th1 or Th2 effectors and adoptive transfer into T cell-deficient recipients, protective capacities were assessed after infection with dif...

The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection.

Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine...

Differential transform method for a a nonlinear system of differential equations arising in HIV infection of CD4+T cell

In this paper, differential transform method (DTM) is described and is applied to solve systems of nonlinear ordinary differential equations which is arising in HIV infections of cell. Intervals of validity of the solution will be extended by using Pade approximation. The results also will be compared with those results obtained by Runge-Kutta method. The technique is described and is illustrat...