Different Patterns of Risk Reducing Decisions in Affected or Unaffected BRCA Pathogenic Variant Carriers
نویسندگان
چکیده
منابع مشابه
Risk-reducing salpingo-oophorectomy for BRCA mutation carriers.
It has been twenty years since the region of the BRCA1mutationwas identified on chromosome 17q. There are now over 3000 risk reducing salpingo-oophorectomy (RRSO) cases reported and an estimated 150 cases describing unsuspected cancers of the ovaries and tubes or in situ lesions. Connor et al. in their current study add to the literature on RRSO outcomes [1]. They report on 345 cases of RRSO in...
متن کاملExperience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier
Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compa...
متن کاملRisk-Reducing Strategies for Ovarian Cancer in BRCA Mutation Carriers: A Balancing Act.
OBJECTIVE The objective of this study was to review the role of bilateral salpingo-oophorectomy in BRCA mutation (mBRCA) carriers and alternative interventions in risk reduction of ovarian cancer (OC). MATERIALS AND METHODS A systematic review using PubMed, MEDLINE, EMBASE, and the Cochrane library was conducted to identify studies of different strategies to prevent OC in mBRCA carriers, incl...
متن کاملReducing Risk or Increasing Profit? Provider Decisions in Agreement Networks
he rise of Software as a Service (SaaS) composition platforms and so called Compute Clouds demonstrates the growing demand for the agile composition of Web Services. In order to facilitate the composition of services and value-creation, service providers need to collaborate. This collaboration is regulated by means of Service Level Agreements (SLAs) where the parties, the executed service as we...
متن کاملRisk-reducing salpingo-oophorectomy: a meta-analysis on impact on ovarian cancer risk and all cause mortality in BRCA 1 and BRCA 2 mutation carriers
BACKGROUND Women with BRCA1 and BRCA2 mutation carriers are at substantially elevated risk of developing ovarian cancer. The aim of the meta-analysis is to clarify the role of risk-reducing salpingo-oophorectomy (RRSO) to reduce ovarian cancer risk and mortality in women with BRCA 1 and BRCA 2 mutation carriers. METHODS Pubmed, Medline and Scopus were searched to select English-language artic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research and Treatment
سال: 2019
ISSN: 1598-2998,2005-9256
DOI: 10.4143/crt.2018.079