Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease

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Different Functional and Microstructural Changes Depending on Duration of Mild Cognitive Impairment in Parkinson Disease.

BACKGROUND AND PURPOSE The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impairment in Parkinson disease. Therefore, our aim was to evaluate the differe...

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Evolution of mild cognitive impairment in Parkinson disease.

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Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment.

We analyzed T1-weighted brain magnetic resonance imaging data of 100 cognitively normal elderly controls (NC), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment (PDMCI) subjects from the Norwegian ParkWest study. Using automated segmentation methods, followed by the radial distance technique and multiple linear regression we studied the effect ...

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ژورنال

عنوان ژورنال: American Journal of Neuroradiology

سال: 2015

ISSN: 0195-6108,1936-959X

DOI: 10.3174/ajnr.a4626