Different effects of global osteopontin and macrophage osteopontin in glomerular injury
نویسندگان
چکیده
منابع مشابه
Are Osteopontin and Ki67 Expressions Different in Various Histologic Grades of Meningioma? An Iranian Experience
Background: Meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. The aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of Iranian people. Methods: In this cross-sectional study, first, the paraffin blocks with the definite pathological dia...
متن کاملSyndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin
Osteopontin (OPN) is a T helper type 1 immunoregulatory cytokine that plays a critical role in various inflammatory disorders. OPN exerts proinflammatory reactions through interaction with integrin receptors. OPN function can be modulated by protease digestion. However, the molecular mechanisms that regulate OPN function in vivo have not been elucidated. There are two putative heparin-binding d...
متن کاملBlockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis.
BACKGROUND In our rat model for anti-GBM GN, severe fibrosis follows glomerular inflammation. A potential role of extracellular matrix protein osteopontin (OPN) in glomerular fibrosis was investigated. METHODS Neutralizing OPN antiserum or control normal serum was injected into the experimental rats at late inflammatory/early fibrotic stage. Glomerular inflammation and fibrosis were determine...
متن کاملThe association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis
BACKGROUND Sarcoidosis is a systemic inflammatory disease of unknown etiology. Osteopontin (SPP1, OPN) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. OBJECTIVE To determine whether plasma OPN levels are elevated in patients with sarcoidosis and compare the frequency of four single nucleotide polymorph...
متن کاملDoes osteopontin induce adipose tissue inflammation by local macrophage proliferation?
In this issue of Molecular Metabolism, Tardelli and colleagues analyzed the impact of osteopontin (OPN) on monocyte and macrophage proliferation in the context of obesity-driven adipose tissue inflammation [1]. Chronic low-grade inflammation of adipose tissue during obesity, a crucial contributor to insulin resistance, type 2 diabetes, and subsequent cardiovascular disease, is associated with a...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2018
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00458.2017