Different approaches for delivering the drug through vesicular carriers
نویسندگان
چکیده
منابع مشابه
Exosomes--vesicular carriers for intercellular communication.
Cells release different types of vesicular carriers of membrane and cytosolic components into the extracellular space. These vesicles are generated within the endosomal system or at the plasma membrane. Among the various kinds of secreted membrane vesicles, exosomes are vesicles with a diameter of 40-100 nm that are secreted upon fusion of multivesicular endosomes with the cell surface. Exosome...
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The history of using vesicular systems for drug delivery to and through skin started nearly three decades ago with a study utilising phospholipid liposomes to improve skin deposition and reduce systemic effects of triamcinolone acetonide. Subsequently, many researchers evaluated liposomes with respect to skin delivery, with the majority of them recording localised effects and relatively few stu...
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Background: Glibenclamide is a lipophilic drug widely used in type 2 diabetes treatment. However, its low bioavailability limits its use. Thus, novel formulations should be applied to improve the drug’s bioavailability. Objectives: This study aimed to develop alternative carriers for oral delivery of glibenclamide. For this purpose, two biocompatible polymers, poly(e-caprolactone) and poly(but...
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Delivery of drug through topical route represents a most convenient and novel approach. The major difficulty arises while delivering a drug through skin is its action as a natural barrier nature which makes it difficult for most drugs to penetrate into and permeate through it. Conventional topical formulations have not proved to be effective in dermal delivery of drug. Novel drug delivery syste...
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ژورنال
عنوان ژورنال: International Journal of Research and Development in Pharmacy & Life Sciences
سال: 2018
ISSN: 2393-932X,2278-0238
DOI: 10.21276/ijrdpl.2278-0238.2018.7(4).3071-3082