Differences of virulence factors, and antimicrobial susceptibility according to phylogenetic group in uropathogenic Escherichia coli strains isolated from Korean patients

Background Escherichia coli is among the most common uropathogens. Increased antibiotic resistance in Gram negative bacilli global concern. Alternative therapeutic options including vaccines against uropathogenic E. (UPEC) have been developed. In this study, we compared genotypic characteristics and antimicrobial susceptibility of UPEC according to phylogenetic groups. Methods We retrospectively reviewed medical records pyelonephritis patients with between February 2015 June 2018. The study was conducted at a center Korea. clinical groups 29 virulence factors were identified using multiplex polymerase chain reaction. Results Phylogenetic group analysis revealed that belonged B2 D: (276, 77.7%), D (62, 17.5%), B1 (12, 3.4%), A (5, 1.4%). Among factors, fyuA, fimH, traT, iutA, papG allele II, papC frequently observed. more closely related sfa/focED, focG, hlyA, cnf1, PAI, than D. Groups showed similar presentations complications. Group had mostly healthcare-associated infections resistance. community-acquired infections. K1 serotype prevalent B2, K5 Conclusions proportions types high presentation adhesions toxins. An increased also noted. Considering genetic UPEC, alternative targeting frequent might be considered addition antibiotics.