Differences in the Brain Cortical Thickness and Area of Different Lobes Between Fetuses with Intrauterine Growth Restriction and Controls Based on 3-Tesla Magnetic Resonance Imaging (MRI)

Background: Intrauterine growth restriction (IUGR) is a major factor in long-term perinatal morbidity and associated with abnormal fetal brain development; however, its pattern of involvement remains unknown. Objectives: This study aimed to investigate the effect IUGR on parenchyma. Patients Methods: Forty-two women pregnancy 28 normally grown fetuses at - 38 weeks underwent 3-tesla magnetic resonance imaging (MRI). Cortical thickness was assessed four regions corrected by biparietal diameter/2. Also, whole surface area (WBA) measured, areas six were calculated WBA. Results: In group, cortical insula temporal lobe significantly thinner than control group (0.034 vs. 0.043 0.036 0.047, respectively; P < 0.05); these also showed reduced WBA (P = 0.028). The not different between groups, except for cerebellum hippocampus, which increased as compared (0.147 0.130 0.017 0.0125, 0.05). Conclusion: fetuses, insular cortex smaller found group. Among regions, hippocampus less affected antenatal period.