Differences in mutagenic and recombinational DNA repair in enterobacteria.
نویسندگان
چکیده
منابع مشابه
Mutagenic DNA repair in enterobacteria.
Sixteen species of enterobacteria have been screened for mutagenic DNA repair activity. In Escherichia coli, mutagenic DNA repair is encoded by the umuDC operon. Synthesis of UmuD and UmuC proteins is induced as part of the SOS response to DNA damage, and after induction, the UmuD protein undergoes an autocatalytic cleavage to produce the carboxy-terminal UmuD' fragment needed for induced mutag...
متن کاملDifferences in mutagenic and recombinational DNA
The incidence of recombinational DNA repair and inducible mutagenic DNA repair has been examined in Escherichia coli and 11 related species of enterobacteria. Recombinational repair was found to be a common feature of the DNA repair repertoire of at least 6 genera of enterobacteria. This conclusion is based on observations of (i) damageinduced synthesis of RecA-like proteins, (it) nucleotide hy...
متن کاملRecombinational DNA Repair in Bacteria: Postreplication
Deoxyribonucleic acid (DNA) damage is a common occurrence in all cells. A bacterial cell growing in an aerobic environment will suffer 3000–5000 DNA lesions per cell per generation (most of them oxidative in origin). Most of this damage is faithfully repaired by specialized DNA repair systems; however, replication forks will occasionally encounter unrepaired DNA lesions. Because DNA polymerase ...
متن کاملFocus on recombinational DNA repair.
Introduction Homologous recombination (HR) has a crucial role in chromosome maintenance by promoting error-free repair of DNA double-strand breaks (DSBs) and single-strand gaps. DNA strand breaks occur spontaneously during normal cellular processes, such as DNA replication, or when cells are treated with DNA damaging agents, and are essential intermediates in several programmed genome rearrange...
متن کاملRecombinational DNA repair: the ignored repair systems.
The recent finding of a role for the recA gene in DNA replication restart does not negate previous data showing the existence of recA-dependent recombinational DNA repair, which occurs when there are two DNA duplexes present, as in the case for recA-dependent excision repair, for postreplication repair (i.e., the repair of DNA daughter-strand gaps), and for the repair of DNA double-strand break...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1985
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.82.12.4172