Dietary supplement with vitamin C prevents nitrate tolerance.

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Dietary supplement with vitamin C prevents nitrate tolerance.

Enhanced formation of superoxide radicals has been proposed to play a major role in the development of nitrate tolerance in humans. We tested the effects of vitamin C (Vit-C) supplementation on glyceroltrinitrate (GTN)-induced hemodynamic effects during 3-d nonintermittent transdermal administration of GTN (0.4 mg/h) in nine healthy subjects. Tolerance development was monitored by changes in ar...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1998

ISSN: 0021-9738

DOI: 10.1172/jci977