Dietary restriction enhances germline stem cell maintenance
نویسندگان
چکیده
منابع مشابه
Heterochromatin components in germline stem cell maintenance
Stem cell maintenance requires expression of genes essential for stemness and repression of differentiation genes. How this is achieved remains incompletely understood. Here we investigate the requirement for central components of heterochromatin, Heterochromatin Protein 1 (HP1) and the histone H3 lys9 methyltransferase Su(var)3-9, in the Drosophila male germline stem cell (GSC) self-renewal, a...
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In many animals there is an apparent trade-off between reproduction and lifespan. Reproductive capacity is often determined by germ line stem cell (GLSC) function. These cells undergo self-renewing divisions to give rise to a gametogenic daughter cell that differentiates into one or more gametes, and a stem cell daughter that remains in the stem cell niche. If GLSC aging is slow or their mitose...
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Epigenetic regulation plays critical roles in the regulation of cell proliferation, fate determination, and survival. It has been shown to control self-renewal and lineage differentiation of embryonic stem cells. However, epigenetic regulation of adult stem cell function remains poorly defined. Drosophila ovarian germline stem cells (GSCs) are a productive adult stem cell system for revealing r...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2010
ISSN: 1474-9718
DOI: 10.1111/j.1474-9726.2010.00602.x