Dietary Monounsaturated Fat in Early Life Regulates IGFBP2: Implications for Fat Mass Accretion and Insulin Sensitivity
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چکیده
منابع مشابه
Substituting dietary polyunsaturated fat with monounsaturated fat increases insulin sensitivity in cultured rat hepatocytes.
Increased dietary fat intake generally, and saturated fat specifically, will lead to impairment of insulin action and to development of metabolic syndrome. The aim of this study was to find out changing of hepatic glucose output in dependence of high monounsaturated and high polyunsaturated fat diet and possible direct action of insulin in hepatocytes. Hepatocytes were isolated by a collagenase...
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The evidence is now compelling that an excess supply of fatty acids, beyond that required for energy needs, is a cause of muscle insulin resistance. Intramyocellular triglyceride accumulation is a marker of excess fatty acid supply to muscle, and it is now two decades since an association was recognized between intramyocellular triglyceride accumulation and insulin resistance (1). Arguably, the...
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Recent evidence shows that specific fatty acids affect cell metabolism, modifying the balance between fatty acid oxidation and lipogenesis. These effects may have important implications in addressing the present epidemic of nutrition-related chronic disease. Intake of dietary saturated and n-6 PUFA have increased while n-3 fatty acid intake has decreased. Obesity, type 2 diabetes and insulin re...
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OBJECTIVE We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(P)RR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose tissue (P)RR gene would prevent weight gain and insulin resistance. METHODS An adipose tissue-specific (P)RR knockout (KO) mouse was created by Cr...
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ژورنال
عنوان ژورنال: Obesity
سال: 2011
ISSN: 1930-7381
DOI: 10.1038/oby.2011.55