Dietary Copper Level Affects Copper Metabolism During Lipopolysaccharide-Induced Immunological Stress in Chicks

How dietary copper affects ruminants

Copper metabolism and gut morphology in rainbow trout (Oncorhynchus mykiss) during chronic sublethal dietary copper exposure

Juvenile rainbow trottt (Oncorhynchus mykiss) werc exposed to I I (control), 300 (medium), and 1000 pg Cug-r (high) (as CuSOa.5H2O) in the diet for 28 days at a daily ration of 4%o wet body weight, with a background waterborne Cu concentration of3 pg.L-|. There was no effect ofdietary Cu on growth, condition factor, or food conversion efficiency. Whole-body Cu content increased continuously ove...

Copper overload affects copper and iron metabolism in Hep-G2 cells.

Divalent metal transporter #1 (DMT1) is responsible for intestinal nonheme Fe apical uptake. However, DMT1 appears to have an additional function in Cu transport in intestinal cells. Because the liver has an essential role in body Cu homeostasis, we examined the potential involvement of Cu in the regulation of DMT1 expression and activity in Hep-G2 cells. Cells exposed to 10 microM Cu exhibited...

Copper metabolism in actively growing rainbow trout (Oncorhynchus mykiss): interactions between dietary and waterborne copper uptake.

Juvenile rainbow trout Oncorhynchus mykiss were exposed to diets with low (12.6 nmol g(-1)), normal (50.4 nmol g(-1)) or elevated (4437.5 nmol g(-1)) Cu concentrations in combination with either low (5.8 nmol l(-1)) or normal (48.5 nmol l(-1)) waterborne Cu levels over a 50-day period, during which body mass increased up to fivefold. A nutritional requirement for Cu was demonstrated based on gr...

Effect of dietary copper addition on lipid metabolism in rabbits

The present study was conducted to investigate the effect of copper supplementation on lipid metabolism in rabbits. Our study showed dietary copper addition (5-45 mg/kg) increased body mass gain, but decreased fat and liver weights compared with those in the control group (P < 0.05). Copper (45 mg/kg) addition significantly increased the skeletal muscle weight, but inhibited cytoplasmic lipid a...