Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats

Abstract Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed investigate comparative effects high fat, sucrose and salt-induced IR fatty acid transporter (FATP) glucose (GLUT4) in rats. Results Rats fed with salt diets developed impaired tolerance ( p > 0.05) hyperinsulinemia < compared control group. Myocardial significantly increased 0.001 for IR; 0.01 sucrose-induced fat-induced IR) across all groups control. Fatty also 0.001) diet-induced rats, fat rats 0.05). Conclusions Our results demonstrate that not caloric excess has a potential role alteration myocardial rat.