Did Mitochondria Kill the Frog?

Metabolic syndrome: did the creator kill the creature?

Did Curiosity Kill the Cat? Relationship Between Trait Curiosity, Creative Self-Efficacy and Creative Personal Identity

Abstract The main objective of the study presented in this article was to examine the relationship between trait curiosity and two self-concept constructs which are gaining popularity in the creativity literature – creative self-efficacy (CSE) and creative personal identity (CPI). Although the role of curiosity in creativity seems well established, in fact there is little empirical evidence of ...

"Did the trial kill the intervention?" experiences from the development, implementation and evaluation of a complex intervention

BACKGROUND The development, implementation and evaluation of any new health intervention is complex. This paper uses experiences from the design, implementation and evaluation of a rehabilitation programme to shed light on, and prompt discussion around, some of the complexities involved in such an undertaking. METHODS Semi-structured interviews were conducted with 15 trial participants and fi...

Energization of sodium absorption by the H(+)-ATPase pump in mitochondria-rich cells of frog skin.

The frog skin in vivo is capable of active transepithelial H+ secretion (JH) which is matched by Na+ absorption (JNa). Studies in vitro demonstrate that JH is generated by an H(+)-ATPase pump localized in apical membranes of mitochondria-rich (MR) cells, whereas JNa occurs through an amiloride-sensitive pathway in principal (P) cells. The H+ pump is sensitive to inhibitors of carbonic anhydrase...

FLIPping the kill switch

I t's always wise to consult others before making a big decision, so a cell seeks input from a lot of different proteins before choosing between survival and death by apoptosis. Fricker et al. describe how one particular protein— cFLIP—can nudge a cell in either direction depending on the expression levels of its three different isoforms (1). Cells contemplate suicide in response to a number of...