منابع مشابه
Dictyostelium development: Lower STATs
The discovery of a STAT protein in Dictyostelium indicates that this organism uses phosphotyrosine-SH2-domain signalling during development. Such signalling is lacking in yeast and its appearance may therefore be an early step in the evolution of multicellularity.
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The early events of macrocyst development in Dictyostelium discoideum have been investigated using a new culturing system. When cells of opposite mating-types, HM1 and NC4, are cultured together at the appropriate temperature in the dark, giant cells appear, ingest the surrounding amoebae, and develop into macrocysts. Although these giant cells have been assumed to be the products of the fusion...
متن کاملSTATs and macrophage fusion
Macrophages play a pivotal role in host defense against multiple foreign materials such as bacteria, parasites and artificial devices. Some macrophage lineage cells, namely osteoclasts and foreign body giant cells (FBGCs), form multi-nuclear giant cells by the cell-cell fusion of mono-nuclear cells. Osteoclasts are bone-resorbing cells, and are formed in the presence of RANKL on the surface of ...
متن کاملSTATS 375 - Project Proposal
Belief propagation is a message-passing algorithm for performing inference in graphical models that has been implemented in a variety of domains including artificial intelligence, information theory and statistical physics. As we know, BP provides exact results only on a relatively restrictive subclass of problems, when the graphical model is a tree (or more generally if each connected componen...
متن کاملJAKs, Stats, and CK2?
derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity. Activating mutations in JAK2, a tyrosine kinase that serves as a critical signaling protein for multiple cytokines, are associated with BCR-ABL1–negative myelo-proliferative neoplasms. In this issue of Blood, Zheng and colleagues report that the constitutively activated kinase CK2 binds to JAK2 and is required fo...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1997
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(06)00366-6