Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration
نویسندگان
چکیده
منابع مشابه
Pediatric Hematopoietic Stem Cell Transplantation
The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...
متن کاملETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation
Recent studies have established that hematopoietic stem cells (HSCs) are quiescent in homeostatic conditions but undergo extensive cell cycle and expansion upon bone marrow (BM) transplantation or hematopoietic injury. The molecular basis for HSC activation and expansion is not completely understood. In this study, we found that key developmentally critical genes controlling hematopoietic stem ...
متن کاملERK1 Regulates the Hematopoietic Stem Cell Niches
The mitogen-activated protein kinases (MAPK) ERK1 and ERK2 are among the major signal transduction molecules but little is known about their specific functions in vivo. ERK activity is provided by two isoforms, ERK1 and ERK2, which are ubiquitously expressed and share activators and substrates. However, there are not in vivo studies which have reported a role for ERK1 or ERK2 in HSCs and the bo...
متن کاملProinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the lifetime of an organism. In vertebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising the floor of the dorsal aorta during a brief developmental window. To date, this process has not been replicated in vitro from pluripotent precursors, partly because the full ...
متن کاملCyclin E1 regulates hematopoietic stem cell quiescence
Comment on: Campaner S, et al. Cell Cycle 2013; 12;3663–72; PMID:24091730; http://dx.doi.org/10.4161/cc.26584 Senthil Raja Jayapal and Philipp Kaldis; Institute of Molecular and Cell Biology (IMCB); A*STAR (Agency for Science, Technology and Research); Singapore, Republic of Singapore; National University of Singapore (NUS); Department of Biochemistry; Singapore, Republic of Singapore; *Email: ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.1200.1200