Diaphragm neuromuscular transmission failure in aged rats
نویسندگان
چکیده
منابع مشابه
Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats.
The effect of chronic exogenous testosterone (T) treatment on neuromuscular transmission in the diaphragm (Dia) muscle of adult male rats was determined. The contribution of neuromuscular transmission failure (NTF) to Dia fatigue was evaluated by superimposing intermittent direct muscle stimulation on repetitive nerve stimulation of isometric contraction in vitro. T treatment significantly redu...
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Meptazinol has been shown to have significant effects on neuromuscular transmission in the isolated rat phrenic nerve-diaphragm preparation. The response of the preparation to indirect electrical stimulation was increased in a concentration-dependent manner by meptazinol hydrochloride 2-32 micrograms ml-1. Meptazinol 0.5-2 micrograms ml-1 antagonized the effects the tubocurarine on this prepara...
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1. Some aspects of the pharmacology of neuromuscular transmission have been studied in the isolated diaphragm of the normal and dystrophic mouse. 2. The effects of (+)-tubocurarine and atropine on the indirectly elicited twitch responses of the dystrophic diaphragm were indistinguishable from normal. 3. Intracellular recording techniques revealed no significant differences between the rise time...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2019
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00061.2019