Diagnostics and age-related evolution of Lennox–Gastaut syndrome. Management in diverse patient age periods

Lennox–Gastaut syndrome is an epileptic encephalopathy with onset in childhood. The classical triad of diagnostic criteria well known: 1) presence various types refractory seizures (tonic, atypical absences, myoclonic, tonic/atonic drop attacks, generalized tonic-clonic, focal); 2) cognitive disorders frequent behavioral (not always evident by the beginning seizures); 3) generalized, slow (≤2.5 Hz) spike-wave activity wakefulness and paroxysmal fast on sleep electroencephalogram. Despite seizure usually occurring before age 8 (peak at 3–5) years old, often featured a lifelong course. Many patients this suffer from epilepsy adulthood, however, not being provided proper syndromological diagnosis. Expanding to diagnose discussed here would allow choose treatment algorithm. Rufinamide drug second choice adjunctive therapy associated syndrome. However, pediatric-to-adult clinic transition may pose some obstacles. Herein, effective patient management requires only control, but also improvement patient's quality life influencing issues, disorders, disability (both physical social), educational problems employment.