Diagnostic value of the post-captopril test in primary aldosteronism

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Diagnostic value of the post-captopril test in primary aldosteronism.

Primary aldosteronism is a disorder with hypertension, hypokalemia, increased plasma aldosterone, and suppressed renin activity. A random plasma aldosterone/renin activity (PA/PRA) >65 (conventional units ratio [CUR] >30) has been proposed as a screening test. We have retrospectively determined the value of the post-captopril plasma aldosterone/renin activity (CAPT PA/PRA) test for the diagnosi...

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Primary aldosteronism: diagnostic accuracy of the losartan and captopril tests.

BACKGROUND To assess whether angiotensin-II receptor blockers (ARBs) offer any additional advantage in confirming the diagnosis of primary aldosteronism (PA) and their use in the differentiation of PA subtypes. METHODS A prospective, cohort, head-to-head study was conducted between July 2003 and July 2006. A total of 135 patients received captopril and losartan tests to confirm the diagnosis ...

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Clinical evaluation of the captopril screening test for primary aldosteronism.

In order to investigate the validity of angiotensin converting enzyme inhibition with captopril as a screening test for primary aldosteronism (PA), 50 mg of captopril were administered orally to 7 patients with PA, 17 with essential hypertension (EH), 5 with renovascular hypertension (RVH), 2 with renoparenchymal hypertension (RH) and 8 normal volunteers. The plasma aldosterone concentration (P...

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Captopril test can give misleading results in patients with suspect primary aldosteronism.

Captopril Test Can Give Misleading Results in Patients With Suspect Primary Aldosteronism To the Editor: Primary aldosteronism (PA) has emerged as the most common form of secondary hypertension.1 The widespread use of the plasma aldosterone/plasma renin activity ratio as a screening test for both hypokalemic and normokaliemic hypertensive subjects has allowed the demonstration of a high prevale...

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Captopril suppression versus salt loading in confirming primary aldosteronism.

This prospective study was designed to compare the captopril suppression test with the salt-loading approach to confirm the diagnosis of primary aldosteronism. A total of 49 patients were referred with a presumed diagnosis of primary aldosteronism. The captopril test was performed in the morning with patients in the seated position after overnight fasting. Blood samples for plasma aldosterone w...

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ژورنال

عنوان ژورنال: American Journal of Hypertension

سال: 2000

ISSN: 0895-7061

DOI: 10.1016/s0895-7061(00)01151-1