Diagnostic Ultrasound and Microbubbles Treatment Improves Outcomes of Coronary No-Reflow in Canine Models by Sonothrombolysis

Incidence and treatment of 'no-reflow' after percutaneous coronary intervention.

BACKGROUND Profound reduction in antegrade epicardial coronary flow with concomitant ischemia is seen occasionally during percutaneous coronary intervention despite the absence of evident vessel dissection, obstruction, or distal vessel embolic cutoff. In a prior small series of cases, this "no-reflow" phenomenon appeared to be promptly reversed by the intra-coronary administration of verapamil...

Demonstration of the "no-reflow" phenomenon by digital coronary arteriography.

6. Kennedy JW, Ritchie JL, Davis KB, Fritz JK. Western Washington rondomized trio1 of intracoronory streptokinase in acute myocordiol infarction. N Engl J Med 1983;309:1477-1482. 7. Schuler G. Schwarz F, Hofmann M, Mehmel H, Manthey J, Maurer W, Rauch B, Herrmann HJ, Kubler W. Thrombolysis in acute myocordiol injarction using intracoronary streptokinose: assessment by thallium-201 scintigraphy....

Sonothrombolysis with BR38 Microbubbles Improves Microvascular Patency in a Rat Model of Stroke

BACKGROUND Early recanalization of large cerebral vessels in ischemic stroke is associated with improved clinical outcome, however persisting hypoperfusion leads to poor clinical recovery despite large vessel recanalization. Limited experimental sonothrombolysis studies have shown that addition of microbubbles during treatment can improve microvascular patency. We aimed to determine the effect ...

The role of vasodilators in the prevention and treatment of no-reflow following percutaneous coronary intervention.

The routine use of vasodilators in patients with acute coronary syndromes or other groups undergoing percutaneous coronary intervention (PCI) cannot be recommended at present. However, in the event of no-reflow occurring following PCI, intracoronary adenosine or verapamil should be administered.

Enhancement of Focused Ultrasound Treatment by Acoustically Generated Microbubbles