Diagnostic performance of the non-invasive myocardial work indices in predicting subclinical myocardial work impairment in Fontan patients

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): public hospital sources. Background The Fontan procedure is an operation that has allowed many paediatric patients suffering from severe congenital heart disease to reach adulthood. More and more frequently we come interface with the consequences Fontan's circulation, such as cardiac function exercise capacity deterioration. Recently new non-invasive method for calculating myocardial work (MW) based on spackle tracking analysis estimation left ventricular pressure measurement blood been introduced. Purpose Aim this study was evaluate diagnostic performance indices in predicting subclinical impairment circulation. Methods A total 69 were included compared healthy age- sex- matched controls (CTRL). Ventricular systolic global longitudinal strain (GLS) assessed. Cardiopulmonary test performed. Global index (MWI) calculated area LV loops. From MWI, Constructive Work (MCW), Wasted (MWW) Efficiency (MWE) estimated. Results two groups comparable pressure, weight end height. Mean age 21.0±9.2 years. MWI (1162 ± 364 mmHg% vs 1777 240 mmHg%, p < 0.001), MCW (1554 450 2102 221 = 0.001) MWE (90 6% 96 2% significantly reduced CTRL. Moreover, GLS (−13,9± 3,1 % −21,2 1.5%, ejection fraction (EF) (58,9 4.5% 63.3 3.9%, 0.002) lower patients. normal EF showed, however, values CTRL (p<0.05). functional right ventricle showed (p 0.030).In univariate analysis, peak VO2 associated age, SatO2, MWI. In multivariate regression, older 0.003) 0.026). Conclusions physiology impaired work. Estimation may be a sensitive indicator able predict capacity.