DIAGNOSIS OF PLEOMORPHIC XANTHOASTROCYTOMA

Introduction. Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic cancer of the central nervous system that classified as grade II according to WHO score. It accounts for 1% primary brain tumors. mainly located in temporal lobe and belongs group tumors called long-term epilepsy associated Surgical tumor resection treatment choice.
 Brief description state knowledge. The non-invasive method PXA diagnostics neuroimaging, which based on computer tomography (CT) magnetic resonance imaging (MRI). In image, presents solid undergoing contrast enhancement, supratentorial, with frequent peripheral cystic components.
 characteristic histologic picture presence highly pleomorphic, fusiform or round, large astrocytes single multiple cell nuclei. Lymphoplasmic infiltrates are visible within tumor. most common mutations occurrence this BRAF V600E gene.
 Conclusions. very (CNS) can recur spread throughout CNS. Imaging tests, i.e. CT MRI, allow precise lesion, however, it necessary perform histopathological examination make final diagnosis. rarity assimilates diagnostic problems. Therefore, further molecular research needed develop more efficient diagnostics.