Diagnosis of Malignant Hyperthermia by Muscle Biopsy. Ca-induced Ca release.
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Sarcoplasmic Reticulum Ca Refilling Controls Recovery From Ca -Induced Ca Release Refractoriness in Heart Muscle
In cardiac muscle Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) is initiated by Ca influx via L-type Ca channels. At present, the mechanisms underlying termination of SR Ca release, which are required to ensure stable excitation-contraction coupling cycles, are not precisely known. However, the same mechanism leading to refractoriness of SR Ca release could also be responsi...
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THIS MONOLOG is part of an APS series on major findings that have shaped many of our present concepts regarding what we currently understand as physiology. The process of Ca-induced Ca release was a topic of much discussion and debate when first introduced. The seminal manuscript on this topic is often considered that of Alexandre Fabiato, “Calcium-induced release of calcium from the cardiac sa...
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We investigated the dependence of nicotinate-adenine dinucleotide phosphate (NAADP)-induced Ca2+ release from intracellular stores of sea urchin egg homogenates, upon extravesicular Ca2+. In contrast to the Ca2+ release induced inositol 1',4',5'-triphosphate (IP3) or cyclic ADP-ribose (cADPR), the Ca2+ release induced by NAADP was completely independent of the free extravesicular Ca2+ over a wi...
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The release of internal Ca from saponin-treated skinned smooth muscle of guinea pig taenia caecum was studied. The amount of Ca released was estimated by the area under the contraction curve during treatment with 25 mM caffeine in the presence of 0.1 mM EGTA. The magnitude of the caffeine response in skinned muscle, after loading with 10(-6) M Ca for 3 min, was similar to that in the depolarize...
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ژورنال
عنوان ژورنال: THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
سال: 1994
ISSN: 0285-4945,1349-9149
DOI: 10.2199/jjsca.14.402