Diabetic Ketoacidosis in Non-Insulin-Dependent Diabetes Mellitus
نویسندگان
چکیده
منابع مشابه
Non-insulin-dependent diabetes mellitus.
Non-insulin-dependent diabetes mellitus (NIDDM) occurs predominantly after the age of 50 years but is not easy to distinguish from late onset insulin-dependent diabetes. It is likely that misclassification is rare in a Caucasian population. Whilst NIDDM is widely believed to be genetically determined, recent epidemiological observations have consistently revealed statistical associations betwee...
متن کاملDiabetic ketoacidosis in type 2 diabetes mellitus.
Diabetic ketoacidosis is usually associated with type 1 diabetes; however, it is increasingly being recognised in type 2 diabetes. The three main mechanisms suggested are: insulinopaenia, elevation in counter-regulatory hormones as a stress response, and increase in free fatty acids. This review aims to highlight the mechanism of diabetic ketoacidosis in type 2 diabetes, the difference compared...
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Diabetic ketoacidosis (DKA) is the culmination of diabetes mellitus that results in unrestrained ketone body formation in the liver, metabolic acidosis, severe dehydration, shock and possibly death. Hepatic lipid metabolism becomes deranged with insulin deficiency and nonesterified fatty acids are converted to acetyl-co-enzyme A (acetyl-CoA) rather than being incorporated into triglycerides. Ac...
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However, it has also been recognized that the treatment of NIDDM patients frequently is inadequate even in those patients who should achieve the target range. In a recent population based cohort the median of glycosylated haemoglobin was 10.2% in NIDDM patients treated with diet or oral hypoglycemic agents (OHA) and 11.8% in NIDDM patients who used insulin. In a 5 year follow-up study of NIDDM ...
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To test the hypothesis that alterations in regulatory regions of the insulin gene occur in a subset of patients with non-insulin-dependent diabetes mellitus (NIDDM), the promoter region was studied by polymerase chain reaction (PCR) amplification directly from genomic DNA, followed by high-resolution polyacrylamide gel electrophoresis under nondenaturing conditions. By using this method a previ...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1998
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689809100112