Diabetes-induced vascular lesion and cognitive dysfunction
نویسندگان
چکیده
منابع مشابه
Diabetes-induced vascular dysfunction involves arginase I.
Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-arginine and by increasing cell proliferation and collagen formation, which promote vascular fibrosis/stiffening. We have shown that increased arginase expression/activity contribute to vascular endothelial cell (EC) dysfunction. Here, we examined the roles of the two arginase isoforms, arginase I and II (AI a...
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متن کاملDiabetes-induced coronary vascular dysfunction involves increased arginase activity.
Increases in arginase activity have been reported in a variety of disease conditions characterized by vascular dysfunction. Arginase competes with NO synthase for their common substrate arginine, suggesting a cause and effect relationship. We tested this concept by experiments with streptozotocin diabetic rats and high glucose (HG)-treated bovine coronary endothelial cells (BCECs). Our studies ...
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ژورنال
عنوان ژورنال: Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
سال: 2015
ISSN: 0915-9401,2188-7519
DOI: 10.16977/cbfm.26.2_129