DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
نویسندگان
چکیده
منابع مشابه
DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.
DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a mechanism currently controversial. Our previous data suggest that DGCR8 trimerizes upon cooperative binding to pri-mir-30a. However, a separate s...
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Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ∼30 bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-binding partner DGCR8. It is not well understood how the Microprocessor specifically recognizes pri-miRNA substrates. Here, we show that in ad...
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ژورنال
عنوان ژورنال: RNA
سال: 2010
ISSN: 1355-8382
DOI: 10.1261/rna.2111310