Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males
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چکیده
منابع مشابه
Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males
Small RNAs play crucial roles in regulating gene expression during mammalian meiosis. To investigate the function of microRNAs (miRNAs) and small interfering RNAs (siRNAs) during meiosis in males, we generated germ-cell-specific conditional deletions of Dgcr8 and Dicer in mice. Analysis of spermatocytes from both conditional knockout lines revealed that there were frequent chromosomal fusions d...
متن کاملDgcr8 and Dicer are essential for sex chromosome integrity in male meiosis
Small RNAs play crucial roles in regulating gene expression during mammalian meiosis. To investigate the function of microRNAs and small-interfering RNAs in male meiosis, we generated germ cell-specific conditional deletions of Dgcr8 and Dicer in mice. Analysis of spermatocytes from both conditional knockout lines reveals frequent chromosomal fusions during meiosis, always involving one or both...
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An asymmetric chromosome pair undergoes synaptic adjustment and crossover redistribution during Caenorhabditis elegans meiosis: implications for sex chromosome evolution.
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2015
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.167148