Developmental expression and differential regulation by retinoic acid ofXenopus COUP-TF-A andCOUP-TF-B
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چکیده
منابع مشابه
Developmental expression and differential regulation by retinoic acid ofXenopus COUP-TF-A andCOUP-TF-B
COUP-TFs (Chicken Ovalbumin Upstream Promoter Transcription Factors) have been proposed to be negative regulators of retinoid receptor-mediated transcriptional activation. In a previous paper we reported the cloning of a Xenopus (x) COUP-TF (Matharu, P.J. and Sweeney, G.E. (1992) Biochim. Biophys. Acta 1129, 331-334). Here we describe the cloning of a second xCOUP-TF. Amino acid sequence compar...
متن کاملRetinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
We have recently described the properties of direct repeats (DRs) of the half-site AGGTCA as hormone response elements (HREs). According to our results, spacing the half sites by 3, 4, or 5 nucleotides determines specificity of response for vitamin D3, thyroid hormone, and retinoic acid receptors, respectively. This so-called 3-4-5 rule led to the prediction that remaining spacing options of 0,...
متن کاملRegulation of laminin gene expression in preimplantation mammalian development by COUP-TF
The deposition of a basement membrane by primitive endoderm cells is necessary for polarization of the epiblast and formation of the proamniotic cavity in periimplantation mammalian embryos. The synthesis of this basement membrane is in turn dependent upon laminin expression. Here we have used embryoid bodies derived from mouse embryonic stem cells to investigate the molecular mechanisms contro...
متن کاملRegulation of laminin and COUP-TF expression in extraembryonic endodermal cells
Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1, and that either COUP-TF is sufficient to induce expression of these laminin genes.
متن کاملModulation of COUP-TF Expression in a Cnidarian by Ectopic Wnt Signalling and Allorecognition
BACKGROUND COUP transcription factors are required for the regulation of gene expression underlying development, differentiation, and homeostasis. They have an evolutionarily conserved function, being a known marker for neurogenesis from cnidarians to vertebrates. A homologue of this gene was shown previously to be a neuronal and nematocyte differentiation marker in Hydra. However, COUP-TFs had...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1996
ISSN: 0925-4773
DOI: 10.1016/0925-4773(95)00471-8