Development of the Amorphous Solid Dispersion of Curcumin: A Rational Selection of Polymers for Enhanced Solubility and Dissolution

The goal of this investigation was to determine the effectiveness hydrophilic polymers in preparing a solid dispersion enhance solubility and dissolution poorly water-soluble drugs, such as curcumin. In order prepare dispersion, curcumin uniformly distributed polymeric matrix polyethylene glycol (PEG 6000), hydroxypropyl methyl cellulose (HPMC E5), polyvinyl pyrrolidine (PVP K30), bovine serum albumin (BSA) using kneading solvent evaporation methods. developed formulations were characterized for solubility, dissolution, Fourier transform infrared (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM), differential calorimetry (DSC). Attaining enhanced physical stability with is crucial selection suitable polymer types ratios. optimized HPMC E5 PVP based displayed 4.3 2.8 times greater compared pure drug, respectively. SEM also showed HPMC-based smoother comparison PVP-based dispersion. XRD DSC validated successful modification crystal structure resulting enhancement its dissolution. conclusion, formulation optimal candidate create amorphous dispersions curcumin, which might be employed an effective delivery system.