Development of Spectrophotometric Method for Quantitative Estimation of Amlodipine Besylate, Olmesartan Medoxomil and Hydrochlorthiazide in Tablet Dosage Form
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چکیده
منابع مشابه
Spectrophotometric Estimation of Amlodipine Besylate in Bulk and in Tablet Dosage Form
A simple UV spectrophotometric method for the analysis of Amlodipine Besylate was developed to analyze the drug in bulk and in tablet formulation. In this method the simple UV spectrum of Amlodipine Besylate in aqueous ethanol (30% v/v) was obtained which exhibits absorption maxima (λ max) at 239.40 nm. The Beers law ranges was followed in the concentration range of 5-60 μg/ml. The proposed met...
متن کاملHPLC method development and validation for simultaneous estimation of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine Besylate tablets
In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...
متن کاملStability-indicating method for simultaneous estimation of olmesartan medoxomile, amlodipine besylate and hydrochlorothiazide by RP-HPLC in tablet dosage form.
A simple, specific, accurate and precise stability-indicating reversed-phase high-performance liquid chromatographic method was developed for simultaneous estimation of olmesartan medoxomile (OLME), amlodipine besylate (AMLO) and hydrochlorothiazide (HCTZ) in tablet dosage form. The method was developed using an RP C18 base deactivated silica column (250 × 4.6 mm, 5 µm) with a mobile phase cons...
متن کاملSimultaneous Estimation of Amlodipine Besylate and Olmesartan Medoxomil in Combined Tablet Dosage Form Using UV-Spectroscopy and Reverse Phase High-Performance Liquid Chromatography Method
Simple, accurate and precise ultraviolet spectrophotometric and reversed-phase high-performance liquid chromatographic (RP-HPLC) methods for simultaneous estimation of amlodipine besylate (AMLO) and olmesartan medoxomil (OLME) in combined tablet dosage form have been developed and validated. Beer’s law was obeyed in the concentration range of 5-70 and 5-60 μg/mL in methanol at 238 nm and 257 nm...
متن کاملUPLCMS Method Development and Validation of Amlodipine, Hydrochlorthiazide and Losartan in Combined Tablet Dosage Form
A simple, rapid, sensitive and specific UPLCMS method was developed and validated following ICH guidelines for simultaneous estimation of tablet dosage form containing amlodipine (AMLO) hydrochlorothiazide (HCT) and losartan (LOSAT) using telmisartan (TELMI) as an internal standard (IS). The separation was achieved using Waters ACQUITY BEH C18 (1.7 μm, 2.1 × 50 mm) column with gradient mode, mo...
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ژورنال
عنوان ژورنال: Pharmaceutica Analytica Acta
سال: 2011
ISSN: 2153-2435
DOI: 10.4172/2153-2435.1000126