Development of Predictive Model for Helper T Lymphocyte Epitope Binding to HLADRB1* 01:01
نویسندگان
چکیده
منابع مشابه
A novel CD4+ T-helper lymphocyte epitope in the VP3 protein of hepatitis A virus.
Prediction analysis of TH-cell epitopes in the VP3 capsid protein of the hepatitis A virus (HAV) revealed the occurrence of a putative TH epitope in the 102-121 region complying with all the algorithms tested. To confirm these predictions, spleen T lymphocytes obtained from BALB/c mice previously immunised with HAV, were stimulated in vitro with different concentrations of synthetic peptides 10...
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We have described a model system in which helper T cells are required to mount a primary antiviral cytolytic T lymphocyte response. The radioresistant helper cell can be found in the spleens of mice that have been immunized subcutaneously with influenza viruses 6-8 d previously. These helper cells appear to be type specific but cross-reactive among the subtypes of influenza A viruses. The pheno...
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INTRODUCTION Class I HLA's polymorphism has hampered CTL epitope mapping with laborious experiments. Objectives are 1) to evaluate the novel in silico model in predicting previously reported epitopes in comparison with existing program, and 2) to apply the model to predict optimal epitopes with HLA using experimental results. MATERIALS AND METHODS We have developed a novel in silico epitope p...
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Understanding the requirements for protection against pneumococcal carriage and pneumonia will greatly benefit efforts in controlling these diseases. Several proteins and polysaccharide capsule have recently been implicated in the virulence of and protective immunity against Streptococcus pneumonia. Pneumococcal surface protein A (PspA) is highly conserved among S. pneumonia strains, inhibits c...
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ژورنال
عنوان ژورنال: Chimica et Natura Acta
سال: 2019
ISSN: 2541-2574,2355-0864
DOI: 10.24198/cna.v7.n2.23713