منابع مشابه
Designing and Development of a DNA Vaccine Based On Structural Proteins of Hepatitis C Virus
Background: Hepatitis C virus (HCV) infection is one of the most prevalent infectious diseases responsible for high morbidity and mortality worldwide. Therefore, designing new and effective therapeutics is of great importance. The aim of the current study was to construct a DNA vaccine containing structural proteins of HCV and evaluation of its expression in a eukaryot...
متن کاملImmunologic Evaluation of DNA Vaccine Encoding Influenza Virus M2 Gene in Type A- Influenza Mice Model
Abstract Background and Objective: The M2 gene expressing the conserved protein in influenza virus can be used to make a single-dose vaccine with permanent immunity. Material and Methods: The mice were allocated to one case group immunized with pcDNA3-M2 and two control groups with pcDNA and PBS, in three dozes with interval of two weeks. Two weeks after the last injection, Cellular imm...
متن کاملDNA Immunization for HIV Vaccine Development
DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future outlook are presented. With better understanding on the potential of DNA immunization and recent pr...
متن کاملDevelopment of novel DNA vaccine for VEGF in murine cancer model
We developed DNA vaccine for vascular endothelial growth factor (VEGF), which may provide the therapeutic option instead of anti-VEGF antibody, bevacizumab. Plasmid containing VEGF mini-gene was constructed in the insertion of B-cell epitope of Hepatitis B core protein [HBc-VEGF], which was an epitope carrier. High titer of anti-VEGF antibody was observed in BALB/c mice which were intramuscular...
متن کاملShigella Vaccine Development: The Model Matters
Bacillary dysentery or shigellosis is mediated by the pathogenic enterobacteria Shigella. Shigella are transmitted through the fecal-oral route, no animal reservoir has been described, and remain a major cause of moderate-severe diarrhea worldwide since no Shigella vaccine is yet commercialized. The design of a pan-Shigella vaccine has been made difficult by the large variety of Shigella specie...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2005
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0006f1