Development of live cultural pandemic influenza vaccine Vector-Flu

Development of live cultural pandemic influenza vaccine Vector-Flu

Background The threat of pandemic A/H1N1 influenza remains a matter of considerable public concern. Recent influenza outbreaks underline the importance of rapid production of a reserve of vaccine sufficient for pandemic and interpandemic periods. Traditional vaccines intended for seasonal influenza do not satisfy this demand, because they are unable to induce cross-reactive antibodies to pandem...

Phase I clinical trials of safety and immunogenicity of live cultural influenza vaccine vector-flu

Background Live influenza vaccines trigger all major components of the anti-flu immune response machinery and have been included in the global WHO program on the pandemic preparedness. Key advantages of using live vaccines include a feasibility of intranasal administration, opportunity to rapidly scale up production of the viral substance, simplicity of vaccination, and robust protection agains...

New Methodological Approaches in The Development of Russian Live Attenuated Vaccine for Pandemic Influenza

Avian influenza viruses remain a major pandemic threat. In response to this threat, a number of pandemic vaccines have been developed. The objective of this paper is to review and summarize data from preclinical and clinical evaluation of Russian live attenuated influenza vaccines (LAIVs) against pandemic influenza based on cold-adapted A/Leningrad/134/17/57 (H2N2) master donor virus (MDV). The...

Pandemic influenza (H1N1) 2009 (swine flu).

new pre pandemic avian flu vaccine progress