منابع مشابه
[Induction of cell differentiation and development of new anticancer drugs].
Cell differentiation is essential for normal growth and homeostasis, and drug-induced differentiation of tumor cells into benign or normal cells is an important approach for anticancer chemotherapy. Studies of induction mechanisms for cell differentiation and discovery of differentiation-inducing factors are thus critical components of drug development. The Screening of differentiation-inducing...
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Liposomes, or phospholipid vesicles, have been recognized as a potential drug delivery vehicle for three decades (1). Depending on the drug of interest, liposomes can serve as a controlled release carrier or simply as a biocompatible solubilizing vehicle for poorly soluble agents. Because of their size, which typically ranges in mean diameter from 50 to 250 nm for the systemically administered ...
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Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure probl...
متن کاملAdvances in the development of hybrid anticancer drugs.
INTRODUCTION Hybrid anticancer drugs are of great therapeutic interests as they can potentially overcome most of the pharmacokinetic drawbacks encountered when using conventional anticancer drugs. In fact, the future of hybrid anticancer drugs is very bright for the discovery of highly potent and selective molecules that triggers two or more cytocidal pharmacological mechanisms of action acting...
متن کاملNew preclinical strategies for characterization and development of anticancer drugs
Karlsson, H. 2017. New preclinical strategies for characterization and development of anticancer drugs. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1378. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0101-3. Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target drive...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2013
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b12-01106