DEVELOPMENT OF HUMAN DERIVED ACELLULAR DERMAL MATRIX: NOVEL TECHNIQUE IN PANDEMIC TIMES
نویسندگان
چکیده
Abstract INTRODUCTION Tissue support is capital to achieve good results in reconstructive and aesthetic surgery. Radiotherapy, infection trauma among others are frequent predictors of surgery failure as they decrease tissue healing capacity. mobilization not always an eligible option raising comorbidities general population elder patients often seen daily practice. Furthermore, the possibility sequels donor zones makes many surgeons be reluctant use flaps, especially In breast surgery, ADMs provide well known benefits such reduced capsule contracture rate improved inframammary fold augmentation procedures METHODS A decellularization protocol proposed by our group obtain biocompatible from cadaveric donors. An experimental animal study designed assess histocompatibility samples influence storage method. Biomechanical tests also done evaluate performance after decellularization. RESULTS Histopathological studies showed no signs acute nor chronic inflammatory response group. Normal fibroblasts growth without early apoptosis samples. properties ensure optimal load tensile strength for most procedures. CONCLUSIONS Current include all steps harvesting donors till matrix process. The result a high valued biomaterial terms biocompatibility security profile available pandemic times. Local production this leads cost minimization derived manufacturing matrices center avoid out-of-stock issues.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znab160.011