Development of a solvent screening methodology for cannabinoid recovery from a wax by-product via recrystallization

Abstract Wax by-products from commercial Cannabis processing, containing between 41 and 46% (w/w) cannabinoids, are currently underutilized due to lack of research done, significant value can be added through recovery the cannabinoids. The cannabinoids aimed recovered via a novel solvent-assisted recrystallization technology, this study provides robust solvent screening methodology for technology. Solvents were screened based on their relative polarity, boiling point temperature, safety use. Further criteria such as reactivity toward wax compounds implemented evaluation Kamlet-Taft parameters potential solvents. Solubility predictions in different solvents done using Hansen solubility (HSP). was tested set 73 commonly used identifying five suitable solvents, which 1,2-dimethoxyethane, 3-pentanone, ethyl acetate, methyl tert-butyl ether. identified use found suitable, validating developed methodology. Graphical