Development of a slow-release device for pocket disinfection

Polyhexanide (polyhexamethylene biguanide) (PHMB) is a polymeric substance that broadly used as disinfectant and antiseptic. It was shown to be suitable for clinical use in critically colonized or infected acute chronic wounds since it exhibits broad antimicrobial spectrum combined with good cell tissue tolerability low risk of contact sensitization. Furthermore wound healing promoting effect reported. The aim this work develop PHMB containing slow release device sustainable disinfection bacterial periodontal pockets other niches the body. A preparation 10% paraffin microcapsules size 200 µm developed. Its releasing properties were investigated vitro using dissolving experiments hanks buffered salt solution (HBSS) without fetal calf serum (FCS), development Streptococcus mitis (S. mitis) growth inhibition zones on blood agar plates mass spectrometry. dissolved constantly over time period 32 days. supernatants from growing S. plates, demonstrated dependent 1948 (24 hours) up 633 (32 days) during whole still present after Mass spectrometry revealed, detectable every point days concentration range 4027 ng/µl 930 days). In conclusion, an anti-infective toxicity, tolerance high antibacterial efficacy which can long-term therapeutic agent slow-release functionality established.