Development of a Novel Artificial Gene Delivery System Multifunctional Envelope-type Nano Device for Gene Therapy
نویسندگان
چکیده
منابع مشابه
[Development of a novel artificial gene delivery system multifunctional envelope-type nano device for gene therapy].
For efficient gene delivery to the nucleus, nonviral vectors need to overcome several barriers such as the plasma membrane, endosomal membrane, and nuclear membrane. To overcome these obstacles, it is necessary to equip the delivery system with various functional devices. However, it is difficult to package all such functional devices into a single system to exert each of their functions at the...
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This review introduces a new concept "Programmed Packaging" to develop a non-viral gene delivery system. Based on this concept, multifunctional envelope type nano devices (MEND) were developed for in vitro, in situ and in vivo conditions. A quantitative study to identify a rate limiting step in intracellular trafficking was also shown between viral and non-viral vectors, which indicated an impo...
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Non-viral vectors need to overcome several barriers such as the plasma membrane, the endosomal membrane and the nuclear membrane for efficient gene delivery to the nucleus of target cells. To overcome these obstacles, the delivery system must be equipped with various functional devices. However, it is difficult to package all these needed devices into a single system to exert each of their func...
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This chapter examines key concepts with respect to cancer gene therapy and the cur‐ rent issues with respect to non-viral delivery. The biological and molecular barriers that need to be overcome before effective non-viral delivery systems can be appropri‐ ately designed for oncology applications are highlighted and ways to overcome these are discussed. Strategies developed to evade the immune r...
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Objective(s): PEI based nanoparticle (NP) due to dual capabilities of proton sponge and DNA binding is known as powerful tool for nucleic acid delivery to cells. However, serious cytotoxicity and complicated conditions, which govern NPs properties and its interactions with cells practically, hindered achievement to high transfection efficiency. Here, we have tried to optimize the properties of ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2007
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.127.1685