Development of a Continuous Photochemical Benzyne-Forming Process

Abstract A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow effectively controls release gaseous by-products based on an adjustable backpressure regulator delivers series heterocyclic products in short residence time 3 minutes. robustness this methodology demonstrated for rapid benzotriazoles, 2H-indazoles various furan-derived adducts, facilitating preparation these important scaffolds via simple readily scalable protocol.