Development, characterization, in vitro and ex vivo evaluation of antiemetic transdermal patches of ondansetron hydrochloride and dexamethasone

The idea of delivering drugs through skin is old, as the use reported back in 16th century B.C. husk castor oil plant water was placed on an aching head. Today transdermal drug delivery well accepted for to systemic circulation. aim this study design a compound patches containing ondansetrone HCL and dexamethasone treatment nausea vomiting case chemotherapy regular symptom vomiting. In present work, attempt has been made develop matrix-type therapeutic system comprising Ondansetron-HCl Dexamethasone different ratios hydrophilic hydrophobic polymeric combinations with 15% w/v plasticizer 5% penetration enhancer were mixed polymer solution using solvent evaporation technique. further subjected various characterization studies prepared along thickness, tensile strength, folding endurance, % elongation, moisture content, uptake, vitro permeation Franz diffusion cells. Obtained results showed no physical-chemical incompatibility between polymers. On basis obtained from, strength (18±0.16), endurance (126 ± 1 68 2), content (2.9±0.4), (92.41 98.9 %), TPEC (Transdermal Patches Ethyl Cellulose) selected optimized formulation. release batch, TPEC-1 followed by zero-order formulation 62.69 within 10 hours. Conclusively, considered deliver safely longer period often.