Development and Validation of Stability Indicating LC Method for Olmesartan Medoxomil
نویسندگان
چکیده
منابع مشابه
Stability Indicating Rp-hplc Method for the Simultaneous Determination of Olmesartan Medoxomil and Atorvastatin Calcium
A simple, rapid, and precise, stability indicating RP-HPLC method for simultaneous analysis of olmesartan medoxomil (OLM) and Atorvastatin (ATR) in bulk has been developed and validated. The analytes were separated by using a Waters symmetry C18 analytical column (250mm × 4.6mm, 5 μm) with a mobile phase consisting of Acetonitrile and 0.02 M potassium dihydrogen phosphate buffer containing 0.1%...
متن کامل“acid- Alkali Degradation Study on Olmesartan Medoxomil and Development of Validated Stability-indicating Chromatographic Methods”
A reversed phase liquid chromatography (RP-HPLC) and thin layer chromatography (HPTLC) densitometry methods as a stability indicating assays of olmesartan medoxomil in presence of its acid or alkaline induced degradation products were developed. Olmesartan medoxomil and its degradation products were analyzed by HPLC equipped with UV-Variable wave length detector at 257 nm where quantitation was...
متن کاملStability Indicating HPLC Method Development and Validation
High performance liquid chromatography (HPLC) is an integral analytical tool in assessing drug product stability. HPLC methods should be able to separate, detect, and quantify the various drug-related degradants that can form on storage or manufacturing, plus detect and quantify any drug-related impurities that may be introduced during synthesis. Forced degradation studies of new chemical entit...
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An isocratic RP-HPLC method was developed for the determination of Cefditoren pivoxil in pharmaceutical formulations using a C-18 column with water-acetonitrile (50:50, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 218 nm). Linearity was observed in the concentration range 1.0-250 μg/mL (R2=0.999) with regression equation y=24194x+10749. The forced degradation studies were perf...
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The stability-indicating LC assay method was developed and validated for quantitative determination of cefozopran hydrochloride (CZH) in the presence of degradation products formed during the forced degradation studies. An isocratic, RP-HPLC method was developed with C-18 (250 mm x 4.6 mm, 5 µm) column and 12 mM ammonium acetate-acetonitrile (92:8, v/v) as a mobile phase. The flow rate of the m...
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ژورنال
عنوان ژورنال: American Journal of Analytical Chemistry
سال: 2012
ISSN: 2156-8251,2156-8278
DOI: 10.4236/ajac.2012.32022