Development and validation of an RP-HPLC method for determination of Metformin and Evogliptin in bulk and pharmaceutical dosage forms
نویسندگان
چکیده
Introduction and Aim: In this study, a new sensitive rapid HPLC method was developed to determine Metformin hydrochloride Evogliptin tartrate in pharmaceutical dosage forms. Materials Methods: Chromatographic separation of achieved on Waters Alliance-e2695 by using XTerra RP-18 150X4.6 mm, 3.5µ column, the mobile phase containing Acetonitrile: KH2PO4: Methanol ratio 50:40:10% v/v. Results: The flow rate 1.0 ml/min; detection carried out absorption at 228 nm photodiode array detector ambient temperature. Conclusion: This simple, economical, suitable, precise, accurate robust for quantitative analysis study its stability.
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ژورنال
عنوان ژورنال: Biomedicine
سال: 2023
ISSN: ['2211-8020', '2211-8039']
DOI: https://doi.org/10.51248/.v43i1.2268