Development and Passive Transfer of Immunity to Gonococcal Infection in Guinea Pigs

Development and passive transfer of immunity to gonococcal infection in Guinea pigs.

Gonococcal infections of relatively long duration were produced in guinea pigs with minimal infective doses ranging from 10(1) to 10(2) colony-forming units. After spontaneous eradication and upon rechallenge with >/=10(8) gonococcal colony-forming units, guinea pigs were refractory to infection. Serum from these guinea pigs was bactericidal in vitro and protected virgin guinea pigs from in viv...

Passive Transfer of Transplantation Immunity Iii. Inbred Guinea Pigs*,

In guinea pigs, when tubercufin sensitivity was passively transferred by lymphoid ceils sensitized to tubercle bacilli and labeled with tritiated thymidine, the transferred ceils were readily identified at the PPD skin test site (1). Further, the transfer of tuberculin sensitivity was not achieved by transferring BCG-sensitized cells enclosed in Millipore chambers (2). In mice, however, when tr...

Gonococcal Infection, Immunity, and Resistance

A comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs

Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (IP) with two strain of B. mallei. Ten male guinea ...

Adoptive transfer of immunity to Treponema pallidum Nichols infection in inbred strain 2 and C4D guinea pigs.

T lymphocytes purified from lymph nodes and spleens of chancre-immune, inbred strain 2 guinea pigs, when infused into syngeneic guinea pigs, conferred protection against challenge with Treponema pallidum subsp. pallidum Nichols. No protection was conferred by similar injections of cell suspensions from normal guinea pigs or guinea pigs immunized with T. phagedenis biotype Reiter or T. pallidum-...