Development and Evaluation of α-Asarone Transdermal Patches Based on Hot-Melt Pressure-Sensitive Adhesives
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چکیده
منابع مشابه
Fabrication of pH sensitive amphiphilic hot-melt pressure sensitive adhesives for transdermal drug delivery system
Based on the blend of styrene-isoprene-styrene (SIS) thermoplastic elastomer and acrylic resin Eudragit EPO, amphiphilic hot-melt pressure sensitive adhesives (HMPSAs) were fabricated. Compatibility and micromorphology of SIS/EPO blends (SEBs) were analyzed with differential scanning calorimetry (DSC), atomic force microscopy (AFM) and scanning electron microscopy (SEM). The results showed that...
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Transdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapo...
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Objective: Azelnidipine, a long-acting dihydropyridine based calcium channel blocker, on oral administration, the drug undergoes extensive first pass metabolism. Delivery of azelnidipine (AZP) via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, is to investigate the development and ev...
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Most of the therapeutic agents are recommended through an oral route, but oral route has disadvantages like first pass metabolism, liver toxicity, etc, due to gastrointestinal pH. This leads poor bioavailability of drugs, which are not stable in G.I pH. To overcome this problem, increase the bioiavailibility, reduce the dose and dose dumping Transdermal delivery system is better option as novel...
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Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topic...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2013
ISSN: 1530-9932
DOI: 10.1208/s12249-012-9915-z