Deuterated Therapeutics: Forensic Toxicology Consequences

Deuterated therapeutics: forensic toxicology consequences.

The toxicology community should be aware that pharmaceutical companies are developing deuterated analogues of therapeutic agents, purported to have improved margins of safety and reduced potential for drug interactions, according to a recent report (1). According to the article in Nature, companies are " snapping up intellectual property rights " on many of the modified drugs. Earlier this year...

Cannabinoids: Forensic Toxicology and Therapeutics

Forensic toxicology.

Forensic toxicology is a discipline of analytical toxicology dedicated to toxicological problems of forensic relevance, for example driving under the influence of alcohol or drugs, or postmortem toxicology. High-quality analytical methods for identification and quantification of drugs, poisons, and/or their metabolites in complex matrices, for example body fluids or hair, are very important in ...

Forensic Medicine and Toxicology

Accident and suicide are the two main epidemiological categories of poisoning; at home and at work are the two main places for it to occur; and clinically it may conveniently be classed as acute or chronic. Availability plays an important part in the incidence of poisoning and in the choice of agent by a person intending suicide, in the substance swallowed by a child, and in the toxic agent aff...

Pharmacogenetics and forensic toxicology.

Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can a...