deTS: tissue-specific enrichment analysis to decode tissue specificity
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چکیده
منابع مشابه
STUDIES ON THE TISSUE SPECIFICITY OF COLONY STIMULATING FACTOR
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Though numerous polymorphisms have been associated with risk of developing lymphoma, how these variants function to promote tumorigenesis is poorly understood. Here, we report that lymphoma risk SNPs, especially in the non-Hodgkin's lymphoma subtype chronic lymphocytic leukemia, are significantly enriched for co-localization with epigenetic marks of active gene regulation. These enrichments wer...
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That certain aspects of susceptibility to transplantable tumors are genetic phenomena has been demonstrated in the case of a carcinoma and a sarcoma of the Japanese Waltzing micel 2 and in two mammary adenocarcinomata occurring in a special strain of highly inbred common domestic mice. 4,5 The acceptance of the view that susceptibility to transplanted neoplasms is fundamentally a genetic proble...
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Rat tumors and other tissues of foreign species grow actively in the chick embryo until the onset of a refractory period. Grafts of rat sarcoma established and growing actively at the onset of this period show a rapid cessation of growth between the 18th and 19th days of incubation. This is followed by a widespread degeneration of the rat cells and a marked activity of the connective tissue ele...
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BACKGROUND Gene set enrichment analysis (GSEA) is an analytic approach which simultaneously reduces the dimensionality of microarray data and enables ready inference of the biological meaning of observed gene expression patterns. Here we invert the GSEA process to identify class-specific gene signatures. Because our approach uses the Kolmogorov-Smirnov approach both to define class specific sig...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2019
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btz138