Determining Optimal Statin Dosage

Determining the optimal 5-FU therapeutic dosage in the treatment of colorectal cancer patients

Fluorouracil (5-FU) has been wildly used as a primary medication in the treatment of solid tumors including colorectal cancer. The treatment efficacy and toxicity of 5-FU varies greatly among individuals, suggesting a need for individualized regimen for cancer patients. The present study analyzed the blood concentration of 5-FU and its therapeutic efficacy and toxicity, evaluated the relationsh...

Determining the optimal redistribution

The classical redistribution problem aims at optimally scheduling communications when moving from an initial data distribution Dini to a target distribution Dtar where each processor Pi will host a subset P (i) of data items. However, modern computing platforms are equipped with a powerful interconnection switch, and the cost of a given communication is (almost) independent of the location of i...

Determining Optimal Few - Stage Allocation

This paper gives algorithms for the design of optimal experiments involving Bernoulli populations in which allocation is done in stages. It is assumed that the outcomes of the previous stage are available before the allocations for the next stage are decided and that the total sample size for the experiment is xed. At each stage, one must decide how many observations to take and how many to sam...

Optimal Cialis Dosage - Typical Cialis Cost

Optimal administration and dosage of methotrexate.

Methotrexate (MTX) has been used for the treatment of rheumatic diseases, especially rheumatoid arthritis (RA), for some decades now. Although it had been known from pharmacokinetic studies for quite some time already that the bioavailability of MTX is superior when administered parenterally rather than orally, this had never been formally proven to be clinically relevant. In a recent randomise...