منابع مشابه
Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata.
Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC(50) value of 1.5 μM. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodeg...
متن کاملPathomechanisms of bacterial meningitis based on transcriptome analysis: role of kynurenine 3-hydroxylase and galectin-3/-9 in brain injury
Inflammation of the subarachnoid and ventricular space contributes to thedevelopment of brain damage i.e. cortical necrosis and hippocampal apoptosis inpneumococcal meningitis (PM). Galectin-3 and -9 are known pro-inflammatorymediators and regulators of apoptosis. Here, the gene and protein expression profilefor both galectins was assessed in the disease progression of PM. The m...
متن کاملKynurenine hydroxylase: a potential rate-limiting enzyme in tryptophan metabolism.
Phillips, R. S. & Kaufman, S. (1984) J. Biol. Chem. 259,2474-2479 Pogson, C. I., Carpenter, W. R., Cook, J . S., Fisher, M. J., Lomax, M. A,, Salter, M. &Stanley, J . C. (1984) Proc. Nutr. Soc. 43, 119132 Salter, M., Stanley, J. C., Fisher, M. J. & Pogson, C. I. (1984) Biochem. J . 221, 431-438 Shiman, R. & Jefferson, L. S. (1982) J. Biol. Cham. 257, 839-844 Shiman, R., Mortimore, G. E., Schwor...
متن کاملDevelopmental and genetic studies on kynurenine hydroxylase from Drosophila melanogaster.
The level of kynurenine hydroxylase was measured throughout the development of wild type and the eye color mutants v, cn, st, ltd, cd, kar, w, ca, bri and p(P) of Drosophila melanogaster. In all cases except cn a bimodal distribution of enzyme activity during development was observed. Activity is initially detectable in second instar. A maximum is reached in early third instar. Activity decline...
متن کاملQuantitative determination of tryptophan metabolites (via kynurenine) in biologic fluids.
HE POSSIBILITY OF 1)ETERMINING QUANTITATIVF LY some products of tryptophan metabolism (1) has been examined previously by one of the authors. Paper chromatography was used as a tool for the separation of kynurenine, 3-hydroxykynurenine, anthranilic, 3-hydroxyanthranilic, kynurenic, and xanthurenic acids. The purpose of this paper is to report on the quantitative determination of these products ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Fungal Genetics Reports
سال: 1969
ISSN: 1941-4765
DOI: 10.4148/1941-4765.2060