Determinants of hepatotoxicity after repeated supratherapeutic paracetamol ingestion: systematic review of reported cases
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چکیده
منابع مشابه
Hepatotoxicity and persistent renal insufficiency after repeated supratherapeutic paracetamol ingestion in a Chinese boy.
Paracetamol has always been regarded as a useful and safe drug. The risk of toxicity with repeated supratherapeutic paracetamol is an underrecognised condition. We report on a 12-month-old boy who presented with hepatotoxicity, disseminated intravascular coagulation and persistent renal insufficiency 4 days after repeated ingestion of a supratherapeutic dosage of paracetamol. To the best of our...
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In the United States acetaminophen (paracetamol) is the most commonly used nonprescription analgesic. In addition to its nonprescription use, acetaminophen is also a common ingredient of prescription opioid combination products. This case report describes an acetaminophen-related fatality that occurred as a consequence of an unintentional overdose of a prescribed hydrocodone/acetaminophen produ...
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Firstly, the 250-mg/kg dose of rectal paracetamol, which was divided into three doses per day for 3 days (each dose equivalent to 27 mg/kg) were overdoses, because the recommended dose is 10 to 15 mg/kg. However, the authors failed to pinpoint this, and instead focused on the daily dose, which in fact was only at the upper limit of the recommended daily dose. The Pediatric Dosage Handbook recom...
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BACKGROUND Herbal hepatotoxicity is a field that has rapidly grown over the last few years along with increased use of herbal products worldwide. AIMS To summarize the various facets of this disease, we undertook a literature search for herbs, herbal drugs and herbal supplements with reported cases of herbal hepatotoxicity. METHODS A selective literature search was performed to identify pub...
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Paracetamol (acetaminophen) poisoning is common throughout the world. The management of nonstaggered (acute) paracetamol overdose is based on the plasma paracetamol concentration plotted on a treatment nomogram. In the UK there are two treatment lines on this nomogram, with the lower treatment line used for individuals felt to be at 'high risk' of paracetamol-related hepatotoxicity either as a ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2016
ISSN: 0306-5251
DOI: 10.1111/bcp.13028